1. 3C-like Proteinase Protein (His Tag)(Active)
Catalog number:PKSR030465
The viral main proteinase (M pro , also called 3CL pro ), which controls the activities of the coronavirus replication complex.
2. Helicase Protein (His Tag)
Catalog number:PKSR030466
The non-structural protein 13 (nsp13) of 2019-nCoV is a helicase that separates double-stranded RNA or DNA with a 5'-3' polarity, using the energy of nucleotide hydrolysis. A basic biochemical characterization of nsp13 demonstrated that it can unwind both doublestranded DNA and RNA in a 5’-3’ direction, and it can hydrolyze all deoxyribonucleotide and ribonucleotide triphosphates.
3. NSP1 Protein (His Tag)
Catalog number:PKSR030467
The Severe Acute Respiratory Syndrome (SARS) Coronavirus (CoV) is an enveloped, positive-stranded RNA viruses that can cause a severe respiratory disease. Its genome consists of a ∼30 kb linear, non-segmented, capped, polycistronic, polyadenylated RNA molecule, the first two-third of which is directly translated into two large polyproteins.
4. NSP2 Protein (His Tag)
Catalog number:PKSR030468
The positive-stranded RNA genome of the coronaviruses is translated from ORF1 to yield polyproteins that are proteolytically processed into intermediate and mature nonstructural proteins (nsps).
5. NSP7 Protein (His Tag)
Catalog number:PKSR030469
The ∼30kb positive-stranded RNA genome of coronaviruses encodes a replication/transcription machinery that is unusually complex and composed of 16 nonstructural proteins (nsps).
6. NSP8 Protein (His Tag)
Catalog number:PKSR030470
Cleavage by the viral main protease, 3CLpro results in generating the nsp8 protein, The nsp8 protein has been shown to associate with several other nsps and to colocalize with these nsps in cytoplasmic complexes that are important for viral RNA synthesis.
7. NSP10 Protein (His Tag)
Catalog number:PKSR030471
Nsp10 have shown that it is a 15-kDa protein of unknown function that has been shown to interact with itself, nsp1, and nsp7.
8. Papain-Like Protease Protein (Active)
Catalog number:PKSR030472
Replication of severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV) requires proteolytic processing of the replicase polyprotein by two viral cysteine proteases, a chymotrypsin-like protease (3CLpro) and a papain-like protease (PLpro).
9. Guanine-N7_meth Protein (His Tag)
Catalog number:PKSR030473
The nonstructural protein (nsp) 14 of 2019-nCoV was identified as a cap (guanine-N7)-methyltransferase (N7-MTase). Nsp14 of coronaviruses two different activities: an exoribonuclease activity acting on both ssRNA and dsRNA in a 3' to 5' direction and a N7-guanine methyltransferase activity.
1. 3C-like Proteinase Protein (His Tag)(Active)
Catalog number:PKSR030465
The viral main proteinase (M pro , also called 3CL pro ), which controls the activities of the coronavirus replication complex.
2. Helicase Protein (His Tag)
Catalog number:PKSR030466
The non-structural protein 13 (nsp13) of 2019-nCoV is a helicase that separates double-stranded RNA or DNA with a 5'-3' polarity, using the energy of nucleotide hydrolysis. A basic biochemical characterization of nsp13 demonstrated that it can unwind both doublestranded DNA and RNA in a 5’-3’ direction, and it can hydrolyze all deoxyribonucleotide and ribonucleotide triphosphates.
3. NSP1 Protein (His Tag)
Catalog number:PKSR030467
The Severe Acute Respiratory Syndrome (SARS) Coronavirus (CoV) is an enveloped, positive-stranded RNA viruses that can cause a severe respiratory disease. Its genome consists of a ∼30 kb linear, non-segmented, capped, polycistronic, polyadenylated RNA molecule, the first two-third of which is directly translated into two large polyproteins.
4. NSP2 Protein (His Tag)
Catalog number:PKSR030468
The positive-stranded RNA genome of the coronaviruses is translated from ORF1 to yield polyproteins that are proteolytically processed into intermediate and mature nonstructural proteins (nsps).
5. NSP7 Protein (His Tag)
Catalog number:PKSR030469
The ∼30kb positive-stranded RNA genome of coronaviruses encodes a replication/transcription machinery that is unusually complex and composed of 16 nonstructural proteins (nsps).
6. NSP8 Protein (His Tag)
Catalog number:PKSR030470
Cleavage by the viral main protease, 3CLpro results in generating the nsp8 protein, The nsp8 protein has been shown to associate with several other nsps and to colocalize with these nsps in cytoplasmic complexes that are important for viral RNA synthesis.
7. NSP10 Protein (His Tag)
Catalog number:PKSR030471
Nsp10 have shown that it is a 15-kDa protein of unknown function that has been shown to interact with itself, nsp1, and nsp7.
8. Papain-Like Protease Protein (Active)
Catalog number:PKSR030472
Replication of severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV) requires proteolytic processing of the replicase polyprotein by two viral cysteine proteases, a chymotrypsin-like protease (3CLpro) and a papain-like protease (PLpro).
9. Guanine-N7_meth Protein (His Tag)
Catalog number:PKSR030473
The nonstructural protein (nsp) 14 of 2019-nCoV was identified as a cap (guanine-N7)-methyltransferase (N7-MTase). Nsp14 of coronaviruses two different activities: an exoribonuclease activity acting on both ssRNA and dsRNA in a 3' to 5' direction and a N7-guanine methyltransferase activity.
